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研究人员报告了一种具有细胞渗透性的选择性METTL3纳摩尔抑制剂UZH1a，作者感谢合乐HL8合成了UZH1a和UZH1b

2023-07-05
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The methylase METTL3 is the writer enzyme of the N6‐methyladenosine (m6A) modification of RNA.

Here researchers report a nanomolar inhibitor of METTL3 (UZH1a) which is selective and cell‐permeable, while its enantiomer UZH1b is essentially inactive. 

The s thank Medicilon for the synthesis of the UZH1a and UZH1b compounds.

Reference:

Elena V Moroz-Omori, et al. METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes. ChemMedChem. 2021 Oct 6;16(19):3035-3043. doi: 10.1002/cmdc.202100291. 

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